This web page was produced as an assignment for Gen677 at UW-Madison Spring 2013
Myo5a
MYO5a is the gene that encodes the molecular motor protein Myosin Va, found on chromosome 1 in horses and chromosome 15 in humans [1,2]. This protein is predominantly expressed in the central nervous system neurons but is also found in melanocyte pigment cells [3]. Myosin Va is responsible for the distribution of cellular cargo, such as melanosomes and secretory vesicles, within the cell and is highly conserved in eukaryotes [3].The gene contains four different domains; a myosin head motor domain, an IQ calmodulin and light chain binding site region, an alpha helical coiled coil region and a C-terminal DIL domain.
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References
[1] Wade CM, Guilotto E, Sigurdsson S, Zoli M, et al. (2009) Genome sequence, comparative analysis, and population genetics of the domestic horse. Science 6(326) doi:10.1126/science.1178158
[2] U.S National Library of Medicine: Genetics Home Reference. MYO5a. Retrieved Febuary 5, 2013, from http://ghr.nlm.nih.gov/gene/MYO5A
[3] Miyata M, Kishimoto Y, Tanaka M, Hashimoto K, Hirashima N, Murata Y, Kano M, Takagishi Y. (2011). A Role for Myosin Va in Cerebellar Plasticity and Motor Learning: A Possible Mechanism Underlying Neurological Disorders in Myosin Va Disease. J Neurosci 31(16):6067-6078.
[4] Biochemistry of Metabolism: Cell Biology. Myosin. Retrieved March 12, 2013, from http://www.rpi.edu/dept/bcbp/molbiochem/MBWeb/mb2/part1/myosin.htm
[2] U.S National Library of Medicine: Genetics Home Reference. MYO5a. Retrieved Febuary 5, 2013, from http://ghr.nlm.nih.gov/gene/MYO5A
[3] Miyata M, Kishimoto Y, Tanaka M, Hashimoto K, Hirashima N, Murata Y, Kano M, Takagishi Y. (2011). A Role for Myosin Va in Cerebellar Plasticity and Motor Learning: A Possible Mechanism Underlying Neurological Disorders in Myosin Va Disease. J Neurosci 31(16):6067-6078.
[4] Biochemistry of Metabolism: Cell Biology. Myosin. Retrieved March 12, 2013, from http://www.rpi.edu/dept/bcbp/molbiochem/MBWeb/mb2/part1/myosin.htm
Rebecca Blackburn, [email protected], 3/16/13